Tianeptine sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium nnu.

Jiri

Tianeptine sodium nnu bụ tricyclic antidepressant, na usoro antidepressant ya dị iche na tricyclic antidepressants omenala.Ọ nwere ike ịbawanye nchikota nke 5-HT na oghere synapti, ma nwee ike inwe mmetụta nke imeziwanye nhazi nke 5-HT neurons.Enweghị njikọ maka choline ma ọ bụ adrenaline receptors.Mmetụta antidepressant yiri tricyclic, mana ndidi dị mma karịa tricyclic.N'ime nnwale anụmanụ, ọ nwere ike ịbawanye ọrụ nke mkpụrụ ndụ pyramidal na hippocampus ma mee ka mgbake ha dị ngwa mgbe mgbochi ọrụ gasịrị.Akwụkwọ kemịkalụ mụbara nnabata nke serotonin site na neurons dị na cortex ụbụrụ na hippocampus.Ntinye sodium tineptine na tract digestive na-adị ngwa ngwa ma zuru oke.Nkesa ngwa ngwa, PPB ruo 94%.A metabolized kpamkpam na imeju site na β-oxidation na N-demethylation, na mkpochapụ nke T1/2 dị mkpụmkpụ na 2.5h.Obere ọgwụ (8%) wepụrụ na akụrụ, ọkachasị metabolites ya na mmamịrị.Ndị ọrịa nwere ụkọ gbasara akụrụ kpochapụrụ T1/2 maka ogologo 1h.