HU-210 CAS NO: 112830-95-2

HU-210 bụ (-) enantiomer nke 11-OH-D 8-THC-DMH, nke nwere ihe fọrọ nke nta ka ọ bụrụ ọrụ niile nke cannabinoids, ebe (+) entiomer, nke a na-akpọ HU-211, adịghị arụ ọrụ dị ka cannabinoid, ma. na-eme kama dị ka cannabinoid dị ka onye na-emegide NMDA nwere mmetụta neuroprotective.

HU-210 nwere ike ịkwalite mmụba, ma ọ bụghị ọdịiche, nke embrayo hippocampal neural stem cell na progenitor cell site na-arụ ọrụ CB 1 receptor, G i / o protein, na ERK akara n'usoro.Nke a na-abawanye ụba nke akwara na-egosikwa mkpa ọ dị maka mgbochi nchegbu na mmetụta ịda mbà n'obi.

Tinyere cannabinoids sịntetik ndị ọzọ, dị ka WIN 55,212-2 na JWH-133, HU-210 na-echebe megide mbufụt nke ọrịa Alzheimer na-ejikọta beta amyloid, na mgbakwunye na igbochi mmetụ uche na ọnwụ nke akara nrịanrịa.A na-eme ka mmetụta a na-eme ka ọ bụrụ ihe na-adịghị mma site na ntinye nke ndị na-anabata cannabinoid, nke na-egbochi ịmalite sel microglia na-egbuke egbuke.Na mgbakwunye, cannabinoids kpochapụrụ neurotoxicity nke metụtara microglial cell activation na ụdị oke.

HU-210 bụ ihe na-egbu mgbu nke nwere ọtụtụ mmetụta dị ka THC eke.

LD50 ọnụ nke HU-210 bụ 5,000mg/kg na oke na 14,200mg/kg na oke bekee.LDLO (ọnụọgụ kacha egbu egbu) nke HU-210 n'ime mmadụ bụ 143mg/kg.A na-eche na LD50 nke caffeine bụ 150-200 mg / kg.Delta-8-THC LD50 ekwenyebeghị.N'ime ọmụmụ 1973, enwe na nkịta nyere 9,000 mg / kg Delta-8-THC adịghị egbu egbu.