Achọpụtara Etonitat na opioid agonist benzimidazole na njedebe 1950 site na otu ndị nyocha Switzerland na-arụ ọrụ na ụlọ ọrụ ọgwụ CIBA (ugbu a Novartis).Otu n'ime ogige mbụ ndị otu Switzerland mụrụ bụ 1- (beta-diethylaminoethyl) -2-benzyl benzimidazole, nke a chọpụtara na ọ nwere 10% nke ọrụ analgesic morphine na bioassometry rodent.Nchọpụta a gbara ndị otu ahụ ume ka ha malite usoro ọmụmụ ihe gbasara 2-benzyl benzimidazole na iji guzobe mmekọrịta nhazi-ọrụ maka ezinụlọ ọhụrụ a nke ndị na-egbu mgbu.E mepụtara ụzọ njikọ izugbe abụọ iji kwado ogige ndị a.

Usoro nke mbụ gụnyere condensation nke o-phenylenediamine na phenylacetonitrile iji mepụta 2-benzylbenzimidazole.A na-agbazi benzimidazole na 1-chloro-2-dialkyl aminoethane achọrọ ka ọ bụrụ ngwaahịa ikpeazụ.Usoro a kachasị baa uru maka ịkwadebe benzimidazole na-enweghị ihe mgbakwunye na mgbanaka benzene

Ngwakọta kachasị n'ozuzu [4] nke ndị otu Switzerland mepụtara na mbụ gụnyere alkylation nke 2, 4-dinitrochlorobenzene na 1-amino-2-diethylaminoethane iji mepụta N- (β-diethylaminoethyl) -2, 4-dinitroaniline [aka: N' - (2, 4-dinitrophenyl) -n, n-diethyl-ethane-1, 2-diamine.Ihe mgbakwunye 2-nitro dị na ogige 2, 4-dinitroaniline na-ahọrọ ebelata ka ọ bụrụ amines bụ isi kwekọrọ site na iji ammonium sulfide dị ka onye na-ebelata ihe.Ammonium sulfide nwere ike imepụta gas hydrogen sulfide na ọnọdụ site n'ịgbakwunye ihe ngwọta ammonium hydroxide gbanyere mkpọrọgwụ na imeju ya na ngwọta ya.Ihe etiti etolite site na nbibi nke 2-nitro-substituent 2- (β-diethylaminoethyl aminoethyl) -5-nitroaniline, nke na-emeghachi omume na iminoethyl ether hydrochloride nke 4-ethoxy phenylacetonitrile (aka: p-ethoxy benzyl cyanide).Imnoether, 2- (4-ethoxy phenyl) -acetyliminoate ethyl ester hydrochloride, a na-akwado ya dị ka gas site na igbari 4-anọchi benzyl cyanide na ngwakọta nke ethanol anhydrous na chloroform, wee saturating ngwọta na anhydrous hydrogen chloride.Mmeghachi omume n'etiti 2- (beta-dialkyl aminoalkyl amine) -5-nitroaniline na hydrochloride nke iminoethyl ether na-ebute nguzobe nke etonitrazine.Usoro a dabara adaba maka nkwadebe nke 4-, 5-, 6- na 7-nitrobenzimidazole.Nhọrọ nke iminoethers nke phenylacetic acid dochie anya nwere ike inye ogige nwere ọtụtụ ihe mgbakwunye na saịtị benzene 2.

A maara ọtụtụ analogues, naanị ihe ndị ọzọ a ma ama sitere na ọmụmụ ihe mbụ na 1950 bụ clonitacetone, nke na-esighị ike karịa etonissini (ihe dị ka ugboro atọ morphine).N'oge na-adịbeghị anya, ebe ọ bụ na njedebe nke 2018, ọtụtụ analogues ndị mmepụta amalitela ịpụta na ahịa iwu na-akwadoghị gburugburu ụwa, na ogige ndị a ma ama bụ metronidazole, isonidazole na ettazine, ma ndị ọzọ na-anọgide na-apụta.