China Hot ire CAS 7361-61-7 Xylazine cannabinoids ọcha ntụ ntụ

Nkọwa

Xylazine bụ agonist nke ndị na-anabata α2-adrenergic (Ki = 194 nM).Ọ bụ ihe analọgụ nke clonidine, α2-adrenergic agonist receptor agonist eji belata ọbara mgbali.A na-eji Xylazine eme ihe na-akụda mmụọ, mgbakasị ahụ, na analgesia n'ime anụmanụ ndị na-abụghị mmadụ.Ngwaahịa a dịkwa ka ọkọlọtọ ntụaka nyocha.
Onye malitere Xylazine, Bayer

Na-eji

Antinociceptive; Alpha-2 adrenergic agonist
Na-eji

Xylazine bụ klas α2 nke adrenergic agonist receptor.Xylazine bụ analoque clonidine nke na-arụ ọrụ na ndị na-anabata presynaptic na postsynapti dịka 2-adrenergic agonist.
Usoro nrụpụta

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), nke a kwadebere site na 2,6-dimethylaniline na thiophosgene, agbakwunyere dropwise n'oge 15 min na nkwusioru nke ọma nke 15.0 g (0.2 mole) nke 3-aminopropanol-1 in 100 ml nke ether.Eter malitere isi.A na-aga n'ihu na-akpali akpali n'okpuru reflux maka 30 min, wee kpochapụ ether ahụ.A na-eji 100 ml nke hydrochloric acid mejupụta ihe fọdụrụ ma sie ya n'okpuru reflux maka nkeji 30.Mgbe ọ dị jụụ, a na-agbaze ya na mmiri, na-ehichapụ ya na adịghị ọcha, na isi na-ebute site na mgbakwunye nke ngwọta sodium hydroxide.Mgbe recrystallized sitere na benzene-ligroin, ihe na-esi na ya pụta 2- (2,6-dimethyl-phenylamino) -4H-5,6-dihydro-1,3-thiazine, ebe mgbaze 140-142 ° C (na-enye 90% nke usoro iwu. ).
Ọrụ ọgwụgwọ

Analgesic, anestetiiki

Nkọwa zuru oke

Xylazine bụ soluble na methanol (50 mg / ml), na-enye ngwọta doro anya na enweghị agba.Ọ na-agbaze na HCl acid na-agbaze na chloroform.Xylazine fọrọ nke nta ka ọ ghara ịsacha ya na mmiri yana ngwọta alkali.
Omume biochem/physiol

A na-ahụta Xylazine mgbe eji ya na ketamine dị ka ihe anestetiiki siri ike ma dị mma n'anụmanụ nnwale.A maara na ọ na-ebuli mwepụta imeju nke glucose, nke na-eme ka hyperglycemia dịkwuo njọ.
Usoro nke ime ihe

A na-ere Xylazine dị ka nnu hydrochloride ya dị ka Rompun (100 mg / mL) na Anased (20 mg / mL) ngwọta injectable maka nchịkwa intravenous na ịnyịnya na nkịta, n'otu n'otu.Omume nke xylazine nwere ike gbanwee site na nchịkwa nke yohimbine, alkaloid indolalkylamine, nke na-egbochi ndị α2-adrenoreceptors nke xylazine na-akpali.
Profaịlụ nchekwa

Nsi site na ntinye, subcutaneous, na intravenous ụzọ.Mmetụta sistemu mmadụ: mgbanwe na ọrụ moto, ịdaba na ọbara mgbali elu, miosis, mbelata nke pleural, mbelata pulse, ụra.Mgbe ọ na-ekpo ọkụ ka ire ere, ọ na-ewepụta uzuzu na-egbu egbu nke NOx na SOx